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Korean clinical research behind modern HA penile augmentation

A one-page summary of the Korean clinical research on hyaluronic acid penile augmentation. Print this or save it as a PDF to bring to a consultation.

Last reviewed: 2025-06-01

  1. 2003 Early human study Early human HA glans studies Korean researchers reported early human experience using injectable HA for glans augmentation and explored anatomical feasibility.
  2. 2008 Follow-up study Five-year glans follow-up A Korean follow-up study reported persistent effects with partial volume reduction over five years in selected patients.
  3. 2011 Clinical study HA penile-shaft girth enhancement A Korean clinical study evaluated injectable HA for penile-shaft girth enhancement.
  4. 2018 Physician survey Korean real-world practice survey A survey of Korean urologists described accumulated experience with 4,344 HA glans procedures for selected premature-ejaculation patients. This was a physician-recall survey, not a controlled clinical trial.
  5. 2020 Randomized trial Multicenter randomized HA vs PLA trial A patient- and evaluator-blinded Korean randomized trial compared temporary HA and PLA penile augmentation. At 24 weeks, average girth increase was 2.1 cm for HA and 1.6 cm for PLA, with no serious adverse events reported.
  6. 2021 Retrospective study Complication study A Korean-affiliated retrospective study described complications and management following HA penile augmentation, including nodules, bleeding, and infection.
  7. 2023 Consensus statement APSSM consensus The Asia-Pacific Society of Sexual Medicine emphasized objective assessment, psychological and physical evaluation, realistic expectations, specialist expertise, and the lack of complete procedural standardization.

What this research supports

  • HA can temporarily increase penile girth.
  • HA is more reversible than permanent fillers.
  • Patient satisfaction can improve in selected men.
  • Technique, volume, product, and follow-up matter.

What it does not prove

  • That every patient should have treatment
  • That Korean treatment is automatically superior
  • A guaranteed number of centimetres
  • Reliable erect-length enlargement
  • Absence of serious complications
  • A single internationally standardized protocol

Sources

  1. Randomized trial A Comparison Between Hyaluronic Acid and Polylactic Acid Filler Injections for Temporary Penile Augmentation in Patients with Small Penis Syndrome: A Multicenter, Patient/Evaluator-Blind, Comparative, Randomized Trial. — Yang DY, Jeong HC, Ahn ST, et al. Journal of Sexual Medicine, 2020 · doi.org/10.1016/j.jsxm.2019.10.006
  2. Clinical study Penile augmentation with injectable hyaluronic acid gel: an alternative choice for small penis syndrome. — Zhang CL, Quan Y, Li H, et al. Asian Journal of Andrology, 2022 · doi.org/10.4103/aja20223
  3. Clinical study Glans Penis Augmentation Using Hyaluronic Acid Gel as an Injectable Filler. — Moon DG, Kwak TI, Kim JJ. World Journal of Men’s Health, 2015 · doi.org/10.5534/wjmh.2015.33.2.50
  4. Physician survey Practice Patterns Among Korean Urologists for Glans Penis Augmentation Using Hyaluronic Acid Filler in the Management of Premature Ejaculation. — Jeong HG, Ahn ST, Kim JW, et al. Sexual Medicine, 2018 · doi.org/10.1016/j.esxm.2018.06.005
  5. Consensus statement Clinical recommendations on penile reconstructive and prosthetic surgery: a consensus statement from the Asia-Pacific Society of Sexual Medicine. — Chung E, Moon DG, Hui J, et al. Sexual Medicine, 2023 · doi.org/10.1093/sexmed/qfad003
  6. Clinical study Efficacy and safety of newly developed cross-linked dextran gel injection for glans penis augmentation with a novel technique. — Yang DY, Ko K, Lee SH, et al. Asian Journal of Andrology, 2018
  7. Clinical study The effects of penile girth enhancement using injectable hyaluronic acid gel, a filler. — Kwak TI, Oh M, Kim JJ, Moon DG. Journal of Sexual Medicine, 2011
  8. Retrospective study Complications and management of penile augmentation with hyaluronic acid injection. — Quan Y, Gao ZR, Dai X, et al. Asian Journal of Andrology, 2021

This website provides general educational information and does not provide a diagnosis, treatment recommendation, or guarantee of eligibility or outcome. The availability and appropriateness of a procedure depend on an in-person assessment by a licensed medical professional. Seek local medical care promptly if you have urgent symptoms.

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